EPICE-PT - Effective Perinatal Intensive Care in Europe - Portugal
Networks
-
Datasets
-
Variables
-
As part of the "Effective Perinatal Intensive Care in Europe" (EPICE) project, this cohort was set up to investigate the use of evidence-based interventions for prenatal and postnatal care of infants born very preterm (VPT) and to explore the associations between evidence-based care and their health and developmental outcomes.
Subsequent follow-ups aimed to study the health service use and short- and long-term outcomes of children born very preterm in Portugal.
Visit EPICE-PT
| Investigators | Contacts |
|---|---|
|
|
Overview
- Acronym
- EPICE-PT
- Start Year
- 2011
- Follow Up Is Ongoing
- Year of Most Recent Data Collection
- 2021
- New Data Collection planned?
- Yes
- Funding
- The EPICE-PT cohort received funding from the European Union [EPICE project: Seventh Framework Programme (FP7/2007–2013, No 259882); SHIPS project: Horizon 2020 Research and Innovation Programme, No 633724].
Access
Access to external researchers or third parties provided or foreseen.
- Data (questionnaire-derived, measured...)
- Biosamples
- Other access
Study Design
- Study design
- Cohort
- Number of Data Collection Events
- 8
- Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
- 974
- Number of term-born control births included in cohort (live & still births)
- 0
- Supplementary information about number of participants
- 974 VPT births were included: 95 terminations of pregnancy; 155 stillbirths; 724 live births (607 infants discharged alive from the hospital). Informed consent for the follow-up evaluations was obtained for 544 infants.
Marker Paper
1. Barros, H., et. al. Effective perinatal intensive care in europe (EPICE): Descrição do Projeto e primeiros resultados em Portugal. Arquivos de Medicina, 28(6), 183-190. 2. Zeitlin J, Maier RF, Cuttini M, Aden U, Boerch K, Gadzinowski J, Jarreau PH, Lebeer J, Norman M, Pedersen P, Petrou S, Pfeil JM, Toome L, van Heijst A, Van Reempts P, Varendi H, Barros H, Draper ES; EPICE and SHIPS Research Group. Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort. Int J Epidemiol. 2020 Apr 1;49(2):372-386. doi: 10.1093/ije/dyz270.
PUBMED 32031620
- Additional Publications
-
- Rodrigues C, Teixeira R, Fonseca MJ, Zeitlin J, Barros H; Portuguese EPICE (Effective Perinatal Intensive Care in Europe) Network. Prevalence and duration of breast milk feeding in very preterm infants: A 3-year follow-up study and a systematic literature review. Paediatr Perinat Epidemiol. 2018 May;32(3):237-246. doi: 10.1111/ppe.12457.
- Rodrigues C, Severo M, Zeitlin J, Barros H; Portuguese EPICE (Effective Perinatal Intensive Care in Europe) Network. The Type of Feeding at Discharge of Very Preterm Infants: Neonatal Intensive Care Units Policies and Practices Make a Difference. Breastfeed Med. 2018 Jan/Feb;13(1):50-59. doi: 10.1089/bfm.2017.0135.
- Costa R, Johnson S, Cuttini M, Pierrat V, Sarrechia I, Barros H, Zeitlin J. The impact of choice of norms on classification of motor impairment for children born very preterm. Early Hum Dev. 2020 Jul;146:105056. doi: 10.1016/j.earlhumdev.2020.105056.
- Piedvache A, van Buuren S, Barros H, Ribeiro AI, Draper E, Zeitlin J; EPICE Research group. Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age. BMC Med Res Methodol. 2021 Jun 6;21(1):118. doi: 10.1186/s12874-021-01264-3.
- Seppänen AV, Draper ES, Petrou S, Barros H, Andronis L, Kim SW, Maier RF, Pedersen P, Gadzinowski J, Lebeer J, Ådén U, Toome L, van Heijst AFJ, Cuttini M, Zeitlin J; SHIPS Research Group. Follow-up after very preterm birth in Europe. Arch Dis Child Fetal Neonatal Ed. 2021 Feb 10:fetalneonatal-2020-320823. doi: 10.1136/archdischild-2020-320823.
- Rodrigues C, Zeitlin J, Wilson E, Toome L, Cuttini M, Maier RF, Pierrat V, Barros H; EPICE Research Group. Managing mother's own milk for very preterm infants in neonatal units in 11 European countries. Acta Paediatr. 2021 Jan;110(1):123-126. doi: 10.1111/apa.15518.
- Cuttini M, Forcella E, Rodrigues C, Draper ES, Martins AF, Lainé A, Willars J, Hasselager A, Maier RF, Croci I, Bonet M, Zeitlin J. What drives change in neonatal intensive care units? A qualitative study with physicians and nurses in six European countries. Pediatr Res. 2020 Aug;88(2):257-264. doi: 10.1038/s41390-019-0733-9.
- Lorthe E, Moreira C, Weber T, Huusom LD, Schmidt S, Maier RF, Jarreau PH, Cuttini M, Draper ES, Zeitlin J, Barros H; EPICE research group. Unit policies regarding tocolysis after preterm premature rupture of membranes: association with latency, neonatal and 2-year outcomes (EPICE cohort). Sci Rep. 2020 Jun 12;10(1):9535. doi: 10.1038/s41598-020-65201-y.
- Seppänen AV, Sauvegrain P, Draper ES, Toome L, El Rafei R, Petrou S, Barros H, Zimmermann LJI, Cuttini M, Zeitlin J; SHIPS Research Group. Parents' ratings of post-discharge healthcare for their children born very preterm and their suggestions for improvement: a European cohort study. Pediatr Res. 2021 Mar;89(4):1004-1012. doi: 10.1038/s41390-020-01120-y.
- Seppänen AV, Bodeau-Livinec F, Boyle EM, Edstedt-Bonamy AK, Cuttini M, Toome L, Maier RF, Cloet E, Koopman-Esseboom C, Pedersen P, Gadzinowski J, Barros H, Zeitlin J; Effective Perinatal Intensive Care in Europe (EPICE) research group. Specialist health care services use in a European cohort of infants born very preterm. Dev Med Child Neurol. 2019 Jul;61(7):832-839. doi: 10.1111/dmcn.14112.
- Zeitlin J, Manktelow BN, Piedvache A, Cuttini M, Boyle E, van Heijst A, Gadzinowski J, Van Reempts P, Huusom L, Weber T, Schmidt S, Barros H, Dillalo D, Toome L, Norman M, Blondel B, Bonet M, Draper ES, Maier RF; EPICE Research Group. Use of evidence based practices to improve survival without severe morbidity for very preterm infants: results from the EPICE population based cohort. BMJ. 2016 Jul 5;354:i2976. doi: 10.1136/bmj.i2976.
- Draper ES, Manktelow BN, Cuttini M, Maier RF, Fenton AC, Van Reempts P, Bonamy AK, Mazela J, Bᴓrch K, Koopman-Esseboom C, Varendi H, Barros H, Zeitlin JJ; EPICE Cohort. Variability in Very Preterm Stillbirth and In-Hospital Mortality Across Europe. Pediatrics. 2017 Apr;139(4):e20161990. doi: 10.1542/peds.2016-1990.
- El Rafei R, Jarreau PH, Norman M, Maier RF, Barros H, Reempts PV, Pedersen P, Cuttini M, Zeitlin J; EPICE Research Group. Variation in very preterm extrauterine growth in a European multicountry cohort. Arch Dis Child Fetal Neonatal Ed. 2021 May;106(3):316-323. doi: 10.1136/archdischild-2020-319946.
- Draper ES, Zeitlin J, Manktelow BN, Piedvache A, Cuttini M, Edstedt Bonamy AK, Maier R, Koopman-Esseboom C, Gadzinowski J, Boerch K, van Reempts P, Varendi H, Johnson SJ; EPICE group. EPICE cohort: two-year neurodevelopmental outcomes after very preterm birth. Arch Dis Child Fetal Neonatal Ed. 2020 Jul;105(4):350-356. doi: 10.1136/archdischild-2019-317418.
- Bonnet C, Blondel B, Piedvache A, Wilson E, Bonamy AE, Gortner L, Rodrigues C, van Heijst A, Draper ES, Cuttini M, Zeitlin J; EPICE Research Group. Low breastfeeding continuation to 6 months for very preterm infants: A European multiregional cohort study. Matern Child Nutr. 2019 Jan;15(1):e12657. doi: 10.1111/mcn.12657.
Timeline
Portugal
The EPICE-PT cohort included all births (terminations of pregnancy, stillbirths, live births), from 22+0 to 31+6 weeks of gestation, occurred between 1st June 2011 and 31st May 2012.
The EPICE-PT involved all of the public maternity units (n=27) from two Portuguese regions, the Northern and Lisbon and Tagus Valley, as well as three private units from Lisbon.
Selection Criteria
- Countries
-
- Portugal
- Geographical Area
- Northern Region; Lisbon and Tagus Valley Region.
- VPT/VLBW Group Inclusion Criteria
- All births (terminations of pregnancy, stillbirths, live births) between 22+0 and 31+6 weeks of gestation. Births occurred between 1st June 2011 and 31st May 2012.
- Control Group Inclusion Criteria
- n/a
- VPT/VLBW Group Exclusion Criteria
- None
- Control Group Exclusion Criteria
- n/a
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
Perinatal Assessment
|
Perinatal data were collected from obstetric and neonatal medical records using a pretested standardised questionnaire. Data were collected on maternal and infant health characteristics, maternal ... | 2011-06 | 2012-05 |
| 1 |
1 Year Follow up
|
***Follow-up at 1 year of corrected age*** A parental structured questionnaire was applied by phone (short questionnaire), by trained interviewers. This questionnaire focused on hospital ... | 2013-01 | 2013-10 |
| 2 |
2 Year Follow-up
|
***Follow-up at 2 years of corrected age*** EPICE-PT participants were followed up at 2 years of corrected age via a postal questionnaire completed by parents. Neurodevelopment was assessed ... | 2013-08 | 2015-04 |
| 3 |
3 Year Follow-up
|
***Follow-up at 3 years*** A parental structured questionnaire was applied by phone, by trained interviewers. This questionnaire focused on socio-demographic characteristics, health of child, ... | 2014-07 | 2015-10 |
| 4 |
4 Year Follow-up
|
***Follow-up at 4 years*** A parental structured questionnaire was applied by phone (short questionnaire), by trained interviewers. This questionnaire focused on childcare provision, health ... | 2015-10 | 2016-08 |
| 5 |
5.5 Year Follow-up
|
***Follow-up at 5.5 years*** Parents completed a structured questionnaire (electronic, on-site, while children were being assessed) on living arrangements, childcare arrangements, education, ... | 2016-09 | 2018-08 |
| 6 |
7 Year Follow-up
|
***Follow-up at 7 years*** A parental structured questionnaire was applied by phone, by trained interviewers. This questionnaire focused on sociodemographic characteristics, school attendance, ... | 2018-11 | 2019-08 |
| 7 |
8.5 Year Follow-up
|
***Follow-up at 8.5 years*** A parental structured questionnaire was applied by phone, by trained interviewers. This questionnaire focused on child's health, attention-deficit/hyperactivity ... | 2020-02 | 2021-05 |